Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in Caenorhabditis elegans

   Aalimah Akinosho, Joseph Alexander ... Andrés Vidal-Gadea
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A whole-organism landscape of X-inactivation in humans

   Björn Gylemo, Maike Bensberg, Colm E Nestor
3. 1. Cell Biology
   2. Genetics and Genomics

   Kinesin-2 autoinhibition requires elbow phosphorylation

   Guanghan Chen, Zhengyang Guo ... Guangshuo Ou

   Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
4. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Systematic analysis of transcription factor combinatorial binding uncovers TEAD1 as an antagonist of tissue-specific transcription factors in human organogenesis

   Araceli Garcia-Mora, Joshua Mallen ... Nicoletta Bobola
5. 1. Cell Biology
   2. Genetics and Genomics

   Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

   San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo

   Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.
6. 1. Genetics and Genomics

   Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression

   Shengze Yao, Yesu Jeon ... Jeannie T Lee

   Xist RNA’s influence extends beyond the X-chromosome and its autosomal influence can be perturbed genetically and pharmacologically.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Upstream open reading frames buffer translational variability during Drosophila evolution and development

   Yuanqiang Sun, Yuange Duan ... Jian Lu

   Upstream open reading frames (uORFs) function as regulatory elements that buffer translation variability, stabilizing protein expression across animal developmental stages and evolutionary timescales.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

   Hans Tobias Gustafsson, Lucas Ferguson ... Oliver J Rando

   A recently developed RNA cloning protocol efficiently captures both intact and fragmented tRNAs.
9. 1. Genetics and Genomics

   Confirmation of HLA-II associations with TB susceptibility in admixed African samples

   Dayna Adrienne Croock, Yolandi Swart ... Caitlin Uren

   A local-ancestry-aware association model identified a suggestive association peak within the HLA class II region linked to TB in a complex, highly admixed Southern African population.
10. 1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft

    The pro-apoptotic lipid trans-2-hexadecenal impairs mitochondrial protein import and proteostasis by targeting the TOM complex.