Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Fingertip viscoelasticity enables human tactile neurons to encode loading history alongside current force

    Hannes P Saal, Ingvars Birznieks, Roland S Johansson
    Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.
    1. Neuroscience

    Precise spatial tuning of visually driven alpha oscillations in human visual cortex

    Kenichi Yuasa, Iris IA Groen ... Jonathan Winawer
    Separating alpha oscillations from broadband activity reveals that alpha suppression in the human visual cortex is highly localized, and modulates cortical state in a manner consistent with exogenous spatial attention.
    1. Developmental Biology

    BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

    Guozhu Ning, Yu Lin ... Qiang Wang
    BCAS2 directly binds to the Armadillo repeats 9–12 of β-catenin via the coiled-coil domains, sequestering β-catenin within the nucleus and thereby promoting Wnt signaling during primitive hematopoiesis.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A Patel, Albert Cardona, Daniel N Cox
    Functional neural circuit dissection identifies sensorimotor responses to noxious cold in Drosophila larvae revealing complex mechanisms by which nervous systems sense and respond to cold.
    1. Neuroscience

    A multiplex of connectome trajectories enables several connectivity patterns in parallel

    Parham Mostame, Jonathan Wirsich ... Sepideh Sadaghiani
    Parallel connectome trajectories unfold asynchronously across timescales, sustaining a multiplex of functionally distinct brain networks operating at different speeds.
    1. Microbiology and Infectious Disease

    Caffeic acid phenethyl ester protects Clostridioides difficile infection by toxin inhibition and microbiota modulation

    Yan Guo, Yong Zhang ... Jiazhang Qiu
    Caffeic acid phenethyl ester treats Clostridioides difficile infection by neutralizing Clostridioides difficile toxin B and altering the gut microbiota and metabolites.
    1. Computational and Systems Biology

    A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

    Sergiy Libert, Alex Chekholko, Cynthia Kenyon
    A model was developed to predict human biological age from physiological traits, enabling the prediction of future health and mortality and the identification of genetic loci that influence aging.
    1. Epidemiology and Global Health

    A sex-specific Mendelian randomization-phenome-wide association study of body mass index

    Zhu Liduzi Jiesisibieke, Io Ieong Chan ... C Mary Schooling
    Higher body mass index has a wide range of harmful health effects, which sometimes appear to be more pronounced in men, suggesting that higher BMI may be one of the factors contributing to differences in lifespan between men and women.
    1. Neuroscience

    Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI

    Joonas A Autio, Ikko Kimura ... Takuya Hayashi
    Ferumoxytol-enhanced MRI enables high-resolution, laminar mapping of cerebral blood volume in the primate brain, validating core neurovascular features and advancing noninvasive tools for neurometabolic imaging.
    1. Cell Biology
    2. Genetics and Genomics

    Kinesin-2 autoinhibition requires elbow phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.