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Publication Cover

American Journal of Respiratory and Critical Care Medicine

Table of Contents
Volume 211, Issue 6 | June 2025
ISSN: 1073-449X | eISSN: 1535-4970
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Emerging Investigators Highlight

June Highlight
pp. xxiv–xxviii
First Page | PDF (2263 KB) 

Editorials

Standard Risk Scores Inadequately Estimate Subclinical Coronary Artery Disease in Chronic Obstructive Pulmonary Disease
Ashraf Fawzy and Claus F. Vogelmeier
pp. 889–890
First Page | Full Text | PDF (526 KB) | related article 
Lung Function Decline in Smokers with Normal Spirometry: The Devastating Impact of Lung Attacks
Yunus Çolak
pp. 891–892
First Page | Full Text | PDF (509 KB) | related article 
Credible Subgroup Effects in Randomized Clinical Trials
Harm-Jan de Grooth, Nadir Yehya, and Michael O. Harhay
pp. 893–895
First Page | Full Text | PDF (677 KB) | related article 
A New Target from a Target Trial Emulation: Allow Early Assisted Breathing
Andrew J. Admon and Christopher J. Yarnell
pp. 895–897
First Page | Full Text | PDF (584 KB) | related article 
A Twist in the Fibrotic Tale: The Overlooked Vasculopathy in Idiopathic Pulmonary Fibrosis
Adriano R. Tonelli and Sandeep Sahay
pp. 897–898
First Page | Full Text | PDF (509 KB) | related article 
“Diamonds Are Forever”: Novel Vascular Endothelial Growth Factor–Nanodiamond Therapy for the Treatment of Congenital Diaphragmatic Hernia
Andreas Damianos, Bernard Thébaud, and Vladimir V. Kalinichenko
pp. 899–901
First Page | Full Text | PDF (868 KB) | related article 
The Other Side of the Coin of Pulmonary Fungal Diseases: Toward New Paradigms
Manuel Castillejos López and David Martínez Briseño
pp. 901–903
First Page | Full Text | PDF (805 KB) | related article 
Another Act in the Story of Oral Imatinib for Pulmonary Arterial Hypertension
Mardi Gomberg-Maitland and Rogerio Souza
pp. 904–905
First Page | Full Text | PDF (510 KB) | related article 
Simplifying Sotatercept in Pulmonary Arterial Hypertension: Genetic Context Meets Treatment Response
Bradley A. Maron
pp. 906–907
First Page | Full Text | PDF (510 KB) | related article 
Camlipixant: A New Hope for Refractory Chronic Cough?
Imran Satia and Stuart B. Mazzone
pp. 908–910
First Page | Full Text | PDF (692 KB) 
The Saga of Equitable Oxygen Saturation Measurement Continues: The Role of Arterial Blood Gases
Christopher F. Chesley and George L. Anesi
pp. 910–911
First Page | Full Text | PDF (506 KB) | related article 
Post-tuberculosis Sequelae and the Burden of “Long TB”: Continuing TB Care after Treatment Completion
Sara C. Auld and Gregory P. Bisson
pp. 912–913
First Page | Full Text | PDF (565 KB) | related article 
Physicians and Pharma: Uneasy Bedfellows?
Andrew Bush
pp. 913–914
First Page | Full Text | PDF (506 KB) | related article 
2024 American Thoracic Society BEAR Cage Winning Proposal: Endothelial-targeted mRNA Lipid Nanoparticles for Acute Respiratory Distress Syndrome
Eno-Obong I. Essien
pp. 915–917
First Page | Full Text | PDF (714 KB) 

Viewpoint: Turning the Air Blue

Coming Full Circle with Preventive Pulmonary Practice: The American Thoracic Society Vaccine Initiative
Robert Stansbury, George Su, Amy Stern, Anna Hrovat, and Sairam Parthasarathy
pp. 918–921
First Page | Full Text | PDF (535 KB) 
Charting a Path toward Diagnostic Excellence and Equity in Thoracic Oncology: The Critical Role of Interventional Pulmonologists and Oncopulmonologists
Roger Y. Kim, Christopher M. Kapp, Jeffrey Thiboutot, M. Patricia Rivera, and A. Christine Argento
pp. 922–924
First Page | Full Text | PDF (580 KB) 

Pulmonary Perspective

Non–Small Cell Lung Cancer to Small Cell Lung Cancer Transformation: A Clinical Challenge
Kostas A. Papavassiliou, Amalia A. Sofianidi, Vassiliki A. Gogou, Georgios Marinos, and Athanasios G. Papavassiliou
pp. 925–931
First Page | Full Text | PDF (685 KB) 

State of the Art

Mechanical Ventilation in Patients with Acute Brain Injuries: A Pathophysiology-based Approach
Dimitrios Georgopoulos, Shaurya Taran, Maria Bolaki, and Evangelia Akoumianaki
pp. 932–945
Abstract | Full Text | PDF (2103 KB) 

Original Articles

Chronic Obstructive Pulmonary Disease

Prevalence and Clinical Correlates of Radiologically Detected Coronary Artery Disease in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Observational Study
Mairi A. MacLeod, Kristopher D. Knott, James P. Allinson, Lydia J. Finney, Dexter J. Wiseman, Andrew I. Ritchie, Aaron Braddy-Green, Sam Barlett-Pestell, Ralph Lopez, Logan Sun, Philippa Webb, Paras Dalal, Michael Rubens, Simon Davies, Dorian O. Haskard, Anand Devaraj, Gavin C. Donaldson, Ramzi Y. Khamis, Edward D. Nicol, and Jadwiga A. Wedzicha
pp. 946–956
Abstract | Full Text | PDF (1034 KB) | related editorial 
Respiratory Exacerbations and Lung Function Decline in People with Smoking History and Normal Spirometry
Spyridon Fortis, Matthew Strand, Surya P. Bhatt, Patrick Ten Eyck, Linder Wendt, Trisha Parekh, MeiLan K. Han, John E. Hokanson, Gregory Kinney, Jeffrey L. Curtis, Russell P. Bowler, Emily S. Wan, Ken M. Kunisaki, Chris H. Wendt, Elizabeth Regan, Mark Dransfield, James D. Crapo, Edwin K. Silverman, and Alejandro P. Comellas; on behalf of the COPDGene Investigators
pp. 957–965
Abstract | Full Text | PDF (945 KB) | related editorial 

Critical Care

Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome
Ann A. Zalucky, Jose Dianti, Lucile P. A. Neyton, Pratik Sinha, Kathleen D. Liu, Michael A. Matthay, B. Taylor Thompson, Ewan C. Goligher, and Carolyn S. Calfee
pp. 966–974
Abstract | Full Text | PDF (1133 KB) | related editorial 
Early versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation
Carmen A. T. Reep, Evert-Jan Wils, Lucas M. Fleuren, Alexander Breskin, Giacomo Bellani, John G. Laffey, Laurent J. Brochard, Tài Pham, and Leo Heunks; for the WEAN SAFE Investigators
pp. 975–983
Abstract | Full Text | PDF (729 KB) | related editorial 

Interstitial Lung Disease

Serial Pulmonary Hemodynamics in Patients with Idiopathic Pulmonary Fibrosis Listed for Lung Transplant
Steven D. Nathan, Ho Cheol Kim, Christopher S. King, Shambhu Aryal, Christopher Thomas, Zein Kattih, Oksana A. Shlobin, Vikramjit Khangoora, and Abhimanyu Chandel
pp. 984–991
Abstract | Full Text | PDF (1099 KB) | related editorial 

Pediatrics and Lung Development

Prenatal VEGF Nanodelivery Reverses Congenital Diaphragmatic Hernia–associated Pulmonary Abnormalities
Stavros P. Loukogeorgakis, Federica Michielin, Noura Al-Juffali, Julio Jimenez, Soichi Shibuya, Jessica Allen-Hyttinen, Mary Patrice Eastwood, Ahmed S. N. Alhendi, Joseph Davidson, Eleonora Naldi, Panagiotis Maghsoudlou, Alfonso Tedeschi, Sahira Khalaf, Manuela Platé, Camila Fachin, Andre Dos Santos Dias, Nikhil Sindhwani, Dominic Scaglioni, Theodoros Xenakis, Neil Sebire, Monica Giomo, Simon Eaton, Jaan Toelen, Camilla Luni, Piero Pavan, Peter Carmeliet, Francesca Russo, Samuel Janes, Marko Z. Nikolić, Nicola Elvassore, Jan Deprest, and Paolo De Coppi
pp. 992–1006
Abstract | Full Text | PDF (3870 KB) | related editorial 

Pulmonary Infections

Global, Regional, and National Burden of Pulmonary Fungal Infections 1990–2021
Ying Xia, Weiwei Jiang, Xinlin Zhu, Bo Pan, Tianyang Chen, Yan Wang, Wanqing Liao, and Weihua Pan
pp. 1007–1017
Abstract | Full Text | PDF (2586 KB) | related editorial 

Pulmonary Vascular Disease

Positioning Imatinib for Pulmonary Arterial Hypertension: A Dose-Finding Phase 2 Study
Alexander M. K. Rothman, Sofia S. Villar, Jennifer Middleton, Andreas A. Roussakis, Frances Varian, Hamza Zafar, Martin Law, Jane Apperley, Imke H. Bartelink, Medhat M. Said, Juan A. Delgado-SanMartin, David G. Kiely, Luke Howard, Mark Toshner, S. John Wort, and Martin R. Wilkins
pp. 1018–1027
Abstract | Full Text | PDF (1016 KB) | related editorial 
Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR)
David Montani, Vallerie V. McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Pilar Escribano Subias, Jeremy Feldman, Gisela M. Meyer, Karen M. Olsson, Florence Coulet, Solaiappan Manimaran, Yujie Zhao, Anna Lau, Janethe de Oliveira Pena, David B. Badesch, and Marc Humbert
pp. 1028–1037
Abstract | Full Text | PDF (775 KB) | related editorial 

Respiratory Physiology

Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE)
Jaclyn A. Smith, Surinder S. Birring, Michael S. Blaiss, Lorcan McGarvey, Alyn H. Morice, Mandel Sher, Kevin J. Carroll, Margaret Garin, Sylvain Lanouette, Joan Shaw, Ronghua Yang, and Catherine M. Bonuccelli
pp. 1038–1048
Abstract | Full Text | PDF (800 KB) | related letter 

Social Issues, Professional Training, and Ethics

Differences in Arterial Blood Gas Testing by Race and Sex across 161 U.S. Hospitals in Four Electronic Health Record Databases
João Matos, Mahmoud Alwakeel, Sicheng Hao, Dana Naamani, Tristan Struja, Judy Wawira Gichoya, Leo Anthony Celi, Timothy McMahon, Heather A. King, Christopher E. Cox, Warren A. Kibbe, Chuan Hong, and An-Kwok Ian Wong
pp. 1049–1058
Abstract | Full Text | PDF (1079 KB) | related editorial 

Tuberculosis and Mycobacterial Disease

Contribution of Posttuberculosis Sequelae to Life-Years Lost from Tuberculosis Disease in the United States, 2015–2019
Nicolas A. Menzies, Suzanne M. Marks, Yuli L. Hsieh, Nicole A. Swartwood, Garrett R. Beeler Asay, Jacek Skarbinski, C. Robert Horsburgh, and Ted Cohen
pp. 1059–1068
Abstract | Full Text | PDF (640 KB) | related editorial 

Images in Pulmonary, Critical Care, Sleep Medicine and the Sciences

Application of Bronchoscopic Intervention in Pulmonary Mucormycosis
Ruiyue Gao, Huiwen Chu, Yumei Gu, Huqin Yang, Hongjie Li, Bing Sun, Zhaohui Tong, and Lili Xu
pp. 1069–1071
First Page | Full Text | PDF (1062 KB) 
Assessment of Pulmonary Perfusion in a Pediatric Patient with Acute Hypoxic Respiratory Failure Using Electrical Impedance Tomography
Glasiele C. Alcala, Giovanni M. Bruno, Marcus Victor, Alex Blanchette, Lorenzo Berra, and Ryan W. Carroll
pp. e9–e10
First Page | Full Text | PDF (602 KB) 

Correspondence

Camlipixant in Refractory Chronic Cough: A Phase 2a, Randomized Controlled Trial (RELIEF)
Jaclyn A. Smith, Alyn H. Morice, Surinder S. Birring, Sean M. Parker, Paul A. Marsden, John R. Holcomb, Mandel Sher, Bruce M. Prenner, Gary Steven, Kevin J. Carroll, Sylvain Lanouette, Denis Garceau, Laurent Harvey, and Catherine M. Bonuccelli
pp. 1072–1075
First Page | Full Text | PDF (589 KB) 
Association between Industry Payments and Prescription of Inhaled Medications
Hasan Nadeem, Lucas M. Donovan, Laura C. Feemster, David H. Au, William B. Feldman, and Kevin I. Duan
pp. 1076–1078
First Page | Full Text | PDF (556 KB) 
A Pilot Study to Capture Provider Perspectives on Clinically Relevant Effects in Thoracic Transplant Trials
Edward Cantu, Dane Isenberg, Abigail Marquis, Alyster Alcudia, Sophia Yusuf, Aya Saleh, Allie Raevsky, Fan Li, and Michael O. Harhay
pp. 1079–1082
First Page | Full Text | PDF (1051 KB) 
Lung-Distending Pressure During Spontaneous Breathing under Mechanical Ventilation Assessed Using Diaphragm Electrical Activity
Natalie C. Lam, Benjamin Coiffard, Jose Dianti, Christer Sinderby, Jennifer Beck, Niall D. Ferguson, and Ewan C. Goligher
pp. 1082–1084
First Page | Full Text | PDF (702 KB) 
Interstitial Lung Disease and Lung Cancer Associated with a Monoallelic Novel Variant in SFTPB
Jennifer A. Wambach, Lawrence M. Nogee, David R. Spielberg, F. Sessions Cole, Dion M. Roberts, Scarlett Murphy, and Christine K. Garcia
pp. 1085–1088
First Page | Full Text | PDF (829 KB) 
Patient Dignity in Long-Term Recovery among Survivors of Acute Respiratory Failure: A Prospective Cohort Study
Rachel Kohn, Craig Kwiatkowski, Yingying Lu, Taara V. Prasad, Erich Dress, Stefania Scott, Michael O. Harhay, and Rachel A. Hadler
pp. 1089–1092
First Page | Full Text | PDF (795 KB) 
Geographic Variation in Prevalence of Breathlessness: Latitude
David C. Currow, Slavica Kochovska, Max Olsson, and Sungwon Chang
pp. 1092–1093
First Page | Full Text | PDF (570 KB) 
Reply to Currow et al.: Geographic Variation in Prevalence of Breathlessness: Latitude
Rajat Suri, Donald P. Tashkin, Russell G. Buhr, and Igor Z. Barjaktarevic; on behalf of all the authors
pp. 1093–1094
First Page | Full Text | PDF (566 KB) 
Assessing the Correlation between Systemic Inflammation and Ground-Glass Opacities: Beyond a Single Indicator
Rui Zhang, Xi Xi Chen, Jian Ping Zhou, and Qing Yun Li
pp. 1094–1095
First Page | Full Text | PDF (570 KB) 
Reply to Zhang et al.: Assessing the Correlation between Systemic Inflammation and Ground-Glass Opacities: Beyond a Single Indicator
Spyridon Fortis and Alejandro P. Comellas
pp. 1095–1096
First Page | Full Text | PDF (569 KB) 
Clinical Guidelines: Asking the Right Questions to Guide Fungal Infection Management
Ignacio Martin-Loeches and Alejandro H. Rodriguez
pp. 1096–1097
First Page | Full Text | PDF (566 KB) 
Reply to Martin-Loeches and Rodriguez: Clinical Guidelines: Asking the Right Questions to Guide Fungal Infection Management
Oleg Epelbaum, Tina Marinelli, Kelly M. Pennington, Andrew H. Limper, and Chadi A. Hage
pp. 1097–1098
First Page | Full Text | PDF (496 KB) 
Lower IgG Levels Increased Exacerbation Risk in Chronic Obstructive Pulmonary Disease: New Insights for Clinical Practice
Yen-Fu Chen, Jung-Yien Chien, Hao-Chien Wang, and Chong-Jen Yu
pp. 1099–1100
First Page | Full Text | PDF (567 KB) 
The Impact of Comorbidities on Serum IgG Levels and Exacerbation Risk in Chronic Obstructive Pulmonary Disease
Hajime Fujimoto, Taro Yasuma, Corina N. D’Alessandro-Gabazza, Esteban C. Gabazza, Osamu Hataji, and Tetsu Kobayashi
p. 1100
First Page | Full Text | PDF (490 KB) 
Reply to Chen et al. and to Fujimoto et al.
Michael Burnim, Nadia N. Hansel, and Nirupama Putcha
p. 1101
First Page | Full Text | PDF (490 KB) 
Different Ventilation Methods and Reintubation in Obese Patients
Guanyu Yang
p. 1102
First Page | Full Text | PDF (546 KB) 
Reply to Yang: Different Ventilation Methods and Reintubation in Obese Patients
Gonzalo Hernández Martínez and Irene Paredes
pp. 1102–1103
First Page | Full Text | PDF (621 KB) 
HIV, Sepsis, and Postdischarge Mortality in Sub-Saharan Africa
Hisham Al-Ward, Alaa Alnadhary, Wei Chen, and Yi Eve Sun
pp. 1103–1104
First Page | Full Text | PDF (512 KB) 
Reply to Al-Ward et al.: HIV, Sepsis, and Postdischarge Mortality in Sub-Saharan Africa
Matthew J. Cummings, Barnabas Bakamutumaho, and Max R. O’Donnell
p. 1105
First Page | Full Text | PDF (493 KB) 
Respiratory Muscle Training and Weaning
Guanyu Yang and Hailong Bing
p. 1106
First Page | Full Text | PDF (545 KB) 
Reply to Yang and Bing: Respiratory Muscle Training and Weaning
Marine Van Hollebeke, Diego Poddighe, Greet Hermans, Rik Gosselink, and Daniel Langer; on behalf of all the authors
pp. 1106–1107
First Page | Full Text | PDF (566 KB) 

Patient Education/Information Series

10 Steps for Hospitals Facing Intravenous Fluid Shortages
W. Graham Carlos, Susan Pasnick, Charles S. Dela Cruz, and Shazia Jamil; on behalf of the Late Breaking Learning Committee
pp. P7–P9
First Page | PDF (428 KB) 
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