Science Immunology
- Volume 10
- Issue 108
- Jun 2025
ONLINE COVER LNP mRNA Vaccines Get a Boost. Lipid nanoparticle (LNP) mRNA vaccines induce robust immune responses and provide protection against infectious diseases, but this immunity can be short-lived, necessitating frequent booster vaccinations. Aunins et al. investigated how adjuvanting LNP-mRNA vaccines with mRNA encoding the cytokine interleukin-12 (IL-12) influences CD8 T cell responses in mice. Il12 mRNA-LNPs (LNP–IL-12) enhanced antigen-specific CD8 T cell responses and CD8 T cell memory, providing greater protection against bacterial infection and in a mouse model of melanoma. Cytokine-adjuvanted mRNA-LNPs may help future vaccine platforms better tailor the magnitude and nature of the immune response. This month’s cover image features a stylized mRNA-LNP with various lipid (red, coral, and pink) and cholesterol molecules (maroon) encapsulating Il12 mRNA (yellow).
Credit: A. Mastin/Science ImmunologyResearch ArticlesBy
- Cheng Zhong
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- et al.
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance
ReviewsBy
- Shivangi Dave
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Noncanonical functions of T follicular helper cells
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- et al.
Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3
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- Emily A. Aunins
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- et al.
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
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Reviews
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Science Immunology publishes original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques.
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