Translational research articles from across Nature Portfolio

Positive results from a first-in-human clinical trial validate the ANGPTL3–ANGPTL8 complex as a new therapeutic target for reducing triglycerides and, potentially, cardiovascular disease risk.

Portable robots may assist subjects with disabilities. However, upper limb movements are hard to fine-tune. Here, the authors design a personalized AI intention detection model to decode user’s motion intention from IMU and compression sensors.

Positive results from a first-in-human clinical trial validate the ANGPTL3–ANGPTL8 complex as a new therapeutic target for reducing triglycerides and, potentially, cardiovascular disease risk.

Understanding the strength and importance of US government-sponsored patents can help to limit high drug prices as well as constitute a justification to enact reasonable pricing clauses and exercise march-in rights.

Platform-based approaches for gene-editing therapies could markedly improve development efficiency, reduce costs and increase access for patients with rare diseases. Although gene editing has shown remarkable clinical success for a small number of Mendelian disease indications, broader adoption faces substantial hurdles. We propose strategies to overcome these challenges through modular platforms for nonclinical and chemistry, manufacturing and controls (CMC) data reuse, risk-based manufacturing quality, and streamlined umbrella clinical trials for regulatory efficiency and accelerated approval.

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.